Steroid hormone excretion pattern in women with endometrial carcinoma
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چکیده
منابع مشابه
Endometrial leucocytes: expression of steroid hormone receptors.
BACKGROUND Stromal leucocyte populations in human endometrium comprise T cells, macrophages, and phenotypically unusual endometrial granulated lymphocytes. Their proportions vary during the menstrual cycle and, in particular, endometrial granulated lymphocytes increase in number in the late secretory phase. The stimulus responsible for these cyclical changes is unknown but it is likely that the...
متن کاملSteroid hormone profiles in women treated with aminoglutethimide for metastatic carcinoma of the breast.
Recent evidence suggests that aminoglutethimide (AG), a known inhibitor of adrenal steroidogenesis, is a potent blocker of aromatase and thus of estrogen production. These properties of AG have been exploited clinically to reduce the biosynthesis of adrenal estrogen precursors and extraglandular estrogen production in postmenopausal women with metastatic breast carcinoma. In this study, we have...
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BACKGROUND Endometrial cancer, the most common gynecological cancer, is closely associated with endometrial hyperplasia, unopposed estrogen exposure, and genetic alterations. Phosphatase and tensin homologue (PTEN) is a tumor suppressor genes completely lost or mutated in >50% of primary endometrioid endometrial cancers. Estrogen-dependent endometrioid carcinoma is the most common type of endom...
متن کاملSteroid hormone abnormalities in women with severe idiopathic constipation.
Patients with severe idiopathic constipation are almost exclusively women of reproductive age. To investigate the possibility of a sex hormone abnormality in this condition, we have compared a range of sex hormones during the follicular and luteal phases of the menstrual cycle in 23 healthy women (mean age 33 years) with those in 26 patients with severe idiopathic constipation (mean age 32 year...
متن کاملSteroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.
PURPOSE Intratumoral metabolism and synthesis of estrogens are considered to play important roles in the pathogenesis and/or development of human endometrial carcinoma. Steroid sulfatase hydrolyzes biologically inactive estrogen sulfates to active estrogens, whereas estrogen sulfotransferase sulfonates estrogens to estrogen sulfates. However, the status of steroid sulfatase and/or estrogen sulf...
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ژورنال
عنوان ژورنال: Cancer
سال: 1968
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(196811)22:5<988::aid-cncr2820220513>3.0.co;2-n